MULTIPLE OLIGONUCLEOTIDE MOIETIES ON PEPTIDE CARRIER

The present disclosure relates to antisense oligonucleotides (AONs), such as phosphorodiamidate morpholino oligonucleotides (PMOs). The present disclosure further relates to the conjugation of multiple PMOs to cationic cell penetrating peptides (CPPs) to enhance the uptake of PMOs into skeletal and...

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Bibliographic Details
Main Authors LEGER, ANDREW, CLAYTON, NICHOLAS P, NELSON, CAROL A, WEEDEN, TIMOTHY E, WENTWORTH, BRUCE M
Format Patent
LanguageEnglish
French
Published 26.09.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:The present disclosure relates to antisense oligonucleotides (AONs), such as phosphorodiamidate morpholino oligonucleotides (PMOs). The present disclosure further relates to the conjugation of multiple PMOs to cationic cell penetrating peptides (CPPs) to enhance the uptake of PMOs into skeletal and cardiac muscle cells. La présente invention concerne les oligonucléotides antisens (AON), tels que les oligonucléotides morpholino phosphorodiamidates (PMO) La présente invention concerne en outre la conjugaison de PMO multiples avec les peptides de pénétration cellulaire cationiques (CPP) pour améliorer la fixation des PMO dans les cellules des muscles cardiaque et squelettique.
Bibliography:Application Number: CA20152949104