TCR LIBRARIES

The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain from a natural repertoire and a beta chain variable domain from a nat...

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Bibliographic Details
Main Authors VUIDEPOT, ANNELISE BRIGITTE, JAKOBSEN, BENT KARSTEN, LIDDY, NATHANIEL ROSS, MOLLOY, PETER EAMON
Format Patent
LanguageEnglish
French
Published 01.08.2023
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMBINATORIAL CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention relates to a library of particles, the library displaying a plurality of different T cell receptors (TCRs), wherein the plurality of TCRs consists essentially of TCRs comprising an alpha chain variable domain from a natural repertoire and a beta chain variable domain from a natural repertoire, wherein the alpha chain variable10 domain comprises a TRAV12-2 or a TRAV21 gene product and the beta chain variable domain comprises a TRBV6 gene product. La présente invention concerne une banque de particules, la banque présentant une pluralité de différents récepteurs des cellules T (TCR), la pluralité de TCR consistant essentiellement en TCR comprenant un domaine variable de la chaîne alpha provenant d'un répertoire naturel et un domaine variable de la chaîne bêta provenant d'un répertoire naturel, le domaine variable de la chaîne alpha comprenant un produit génique TRAV122 ou TRAV21, et le domaine variable de la chaîne bêta comprenant un produit génique TRBV6.
Bibliography:Application Number: CA20152942433