3,4-DIAMINO-6-CHLORPYRAZINE-2-CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF ENAC MEDIATED DISEASES

The present invention provides a compound of a formula (I): (see formula I) or a pharmaceutically acceptable salt thereof; a process for preparing such a compond; and to the use of such a compound in the ptreatment of an ENaC mediated disease state (such as asthma, CF or COPD). La présente invention...

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Bibliographic Details
Main Authors KRISTOFFERSSON, ANNA, RIPA, LENA ELISABETH, BERGLUND, SUSANNE ELISABETH, HOSSAIN, NAFIZAL, CONNOLLY, STEPHEN, HEMMERLING, MARTIN, LUNDKVIST, JOHAN RUNE MICHAEL, SHAMOVSKY, IGOR, NIKITIDIS, GRIGORIOS
Format Patent
LanguageEnglish
French
Published 07.03.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a compound of a formula (I): (see formula I) or a pharmaceutically acceptable salt thereof; a process for preparing such a compond; and to the use of such a compound in the ptreatment of an ENaC mediated disease state (such as asthma, CF or COPD). La présente invention concerne un composé de formule (I) : ou un sel pharmaceutiquement acceptable de celui-ci; un procédé de préparation d'un tel composé; et l'utilisation d'un tel composé dans le traitement d'un état pathologique à médiation par le canal sodique épithélial (ENaC)(tel que l'asthme, la fibrose kystique ou la bronchopneumopathie chronique obstructive (BPCO)).
Bibliography:Application Number: CA20152941807