BETA HAIRPIN PEPTIDES HAVING ANTI-VIRAL PROPERTIES AGAINST THE DENGUE VIRUS

The invention relates to structurally constrained synthetic peptides that have been optimised to form a beta-hairpin structure. The peptides can inhibit or reduce the infection caused by the dengue virus (DENV). The invention also relates to pharmaceutical compositions containing these synthetic pep...

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Main Authors CHINEA SANTIAGO, GLAY, GUIROLA CRUZ, OSMANY, GARAY PEREZ, HILDA ELISA, HUERTA GALINDO, VIVIAN, VAZQUEZ CASTILLO, MARIELA, REYES ACOSTA, OSVALDO, GONZALEZ BLANCO, SONIA, MARTIN DUNN, ALEJANDRO MIGUEL, MARQUEZ PERERA, GABRIEL JESUS, GONZALEZ LOPEZ, LUIS JAVIER, YERO DIAZ, ALEXIS, FALCON CAMA, VIVIANA, GARATEIX SUAREZ, ROCIO, ALVAREZ PEREZ, KAREN, PUPO GOMEZ, DIANNE, SARRIA NUNEZ, MONICA
Format Patent
LanguageEnglish
French
Published 17.11.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to structurally constrained synthetic peptides that have been optimised to form a beta-hairpin structure. The peptides can inhibit or reduce the infection caused by the dengue virus (DENV). The invention also relates to pharmaceutical compositions containing these synthetic peptides, said pharmaceutical compositions being suitable for preventing and/or treating the infections caused by DENV. Furthermore, the invention provides a method for treating the infections caused by this virus. La présente invention se rapporte à des peptides synthétiques, structuralement limités, qui ont été optimisés pour la formation d'une structure en épingle à cheveux bêta. Les peptides sont capables d'inhiber ou d'atténuer l'infection par le virus de la dengue (DENV). L'invention concerne également des compositions pharmaceutiques qui contiennent ces peptides synthétiques, ces compositions étant utiles pour la prévention et/ou le traitement des infections provoquées par le DENV. De même, l'invention présente une méthode de traitement des infections provoquées par ce virus.
Bibliography:Application Number: CA20152940078