DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA

Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) a...

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Main Authors CLAREMON, DAVID A, LOTESTA, STEPHEN D, YUAN, JING, ZHUANG, LINGHANG, SINGH, SURESH B, TICE, COLIN M, MARCUS, ANDREW, LIU, ZHIJIE, ZHENG, YAJUN, FAN, YI, JIA, LANQI, ZHAO, WEI, DILLARD, LAWRENCE WAYNE, DONG, CHENGGUO
Format Patent
LanguageEnglish
French
Published 07.03.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders. L'invention concerne de nouveaux composés de formule (I) : des sels pharmaceutiquement acceptables de ceux-ci, et des compositions pharmaceutiques de ceux-ci, qui sont utiles dans le traitement de maladies et de troubles à médiation par ROR?. L'invention concerne également des compositions pharmaceutiques comprenant les nouveaux composés de formule (I) et des procédés pour leur utilisation dans le traitement d'un ou de plusieurs troubles ou maladies inflammatoires, métaboliques, auto-immun(e)s et autres.
Bibliography:Application Number: CA20152938311