SOLID FORMS OF 2-(TERT-BUTYLAMINO)-4-((1R,3R,4R)-3-HYDROXY-4-METHYLCYCLOHEXYLAMINO)-PYRIMIDINE-5-CARBOXAMIDE, COMPOSITIONS THEREOF AND METHODS OF THEIR USE

• Main Authors: XU, JEAN, LI, YING, MUSLEHIDDINOGLU, JALE, BEAUCHAMPS, MARIE GEORGES, YONG, KELVIN HIN-YEONG, HUANG, LIANFENG, FERRETTI, ANTONIO CHRISTIAN, KOTHARE, MOHIT ATUL, BOERSEN, NATHAN ANDREW, ZHOU, NANFEI, NAGY, MARK A, HILGRAF, ROBERT, MAN, HON-WAH, ZOU, DAOZHONG
• Format: Patent
• Language: English; French
• Published: 06.08.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Provided herein are formulations, processes, solid forms and methods of use relating to 2-(tert-butylamino)-4-((1R,3R,4R)-3- hydroxy-4-methy1cydohexylamino)-pyrimidine-5-carboxamide (Compound I). In another aspect, provided herein are methods for preparing certain compounds, including Compound I as described herein, as well as intermediates useful in such methods. In certain aspects, the solid forms of Compound I are useful for inhibiting a kinase in a cell expressing said kinase, for example JNK1 or JNK2. In another aspect, the solid forms of Compound I are useful for treating or preventing one or more disorders selected from interstitial pulmonary fibrosis, systemic sclerosis, scleroderma, chronic allograft nephropathy, antibody mediated rejection, or lupus. L'invention porte sur des formulations, des procédés, des formes solides et des méthodes d'utilisation se rapportant au 2- (tert-butylamino)-4-((lR,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5- carboxamide.