(2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS

• Main Authors: AURELL, CARL-JOHAN, SWALLOW, STEVEN, VAN DE POEL, AMANDA JANE, PO KARLSSON, STAFFAN, PALMER, NICHOLAS JOHN, MACRITCHIE, JAQUELINE ANNE, PONTEN, JOHN FRITIOF, CONNOLLY, STEPHEN, WATSON, DAVID WYN, DOYLE, KEVIN JAMES, JONES, GRAHAM PETER, LONN, HANS ROLAND
• Format: Patent
• Language: English; French
• Published: 18.10.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4- oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), (Formula (I)) that inhibit dipeptidyl peptidase 1(DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds. La présente invention concerne certains composés de (2S)-N-[(1S)-1-cyano-2-phényléthyl]-1,4-oxazépane-2-carboxamide (comprenant des sels pharmaceutiquement acceptables correspondants) (formule (I)) qui inhibent l'activité de la dipeptidyl peptidase 1 (DPP1), leur utilité dans le traitement et/ou la prévention d'affections cliniques comprenant les maladies respiratoires, telles que l'asthme et la bronchopneumopathie chronique obstructive (BPCO), leur utilisation en thérapie, des compositions pharmaceutiques les contenant et des procédés pour préparer ces composés.