TOPICAL DELIVERY OF SKIN COMPOSITIONS HAVING LOW PH

Low pH compositions for topical administration to skin are provided. They comprise a buffering agent having a pKa of about 2.8 to about 4.2 and a cosmetically acceptable active ingredient having a pKa within about 1 unit of the pKa of the buffering agent. The composition has a pH of about 3.3 to 4 a...

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Main Authors YATES, ROBERT WAYNE, HU, YA-PING, SUN, YING, BRILLOUET, ANNE-SOPHIE, DUFORT, MARISA DEVITA, GARCIA, DEVIN L, FASSIH, ALI, PARSA, RAMINE, ROSSETTI, DIANNE, PATURI, JYOTSNA, LI, WEN-HWA TING, WANGARI-TALBOT, JANET
Format Patent
LanguageEnglish
French
Published 10.10.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Summary:Low pH compositions for topical administration to skin are provided. They comprise a buffering agent having a pKa of about 2.8 to about 4.2 and a cosmetically acceptable active ingredient having a pKa within about 1 unit of the pKa of the buffering agent. The composition has a pH of about 3.3 to 4 and a buffer capacity of at least about 0.15. A method of increasing the topical delivery of a cosmetically acceptable active ingredient having a pKa of about 2.8 to about 4 is also provided. Il est décrit des compositions à faible pH pour ladministration topique sur la peau. Elles comprennent un agent tampon ayant une valeur du pKa denviron 2,8 à environ 4,2 et un principe actif acceptable sur le plan cosmétique ayant une valeur du pKa inférieure à environ une unité du pKa de lagent tampon. La composition a un pH denviron 3,3 à 4,0 et un pouvoir tampon dau moins 0,15 environ. Il est également décrit une méthode permettant daugmenter ladministration topique dun principe actif acceptable sur le plan cosmétique ayant une valeur du pKa denviron 2,8 à environ 4,0.
Bibliography:Application Number: CA20162935367