3-(5-CHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID DERIVATIVES AS KMO INHIBITORS
A compound of formula (I) or a salt thereof are provided wherein R1, X and R3 are defined in the specification, useful in the treatment of disorders mediated by KMO such as acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Hu...
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Main Authors | , , , |
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Format | Patent |
Language | English French |
Published |
11.01.2022
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Subjects | |
Online Access | Get full text |
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Summary: | A compound of formula (I) or a salt thereof are provided wherein R1, X and R3 are defined in the specification, useful in the treatment of disorders mediated by KMO such as acute pancreatitis, chronic kidney disease, other conditions associated with systemic inflammatory response syndrome (SIRS), Huntington's disease, Alzheimer's disease, spinocerebellar ataxias, Parkinson's disease, AIDS-dementia complex, amylotrophic lateral sclerosis (ALS), depression, schizophrenia, sepsis, cardiovascular shock, severe trauma, acute lung injury, acute respiratory distress syndrome, acute cholecystitis, severe burns, pneumonia, extensive surgical procedures, ischemic bowel, severe acute hepatic disease, severe acute hepatic encephalopathy or acute renal failure.
La présente invention concerne un composé de formule (I) ou son sel, R1, X et R3 étant définis dans les spécifications, utile dans le traitement de troubles induits par la KMO tels que la pancréatite aiguë, la maladie rénale chronique, d'autres états associés au syndrome de réponse inflammatoire systémique (SIRS), la maladie de Huntington, la maladie d'Alzheimer, l'ataxie spinocérébelleuse, la maladie de Parkinson, le complexe SIDA-démence, la sclérose latérale amyotrophique, la dépression, la schizophrénie, la sepsie, le choc cardiovasculaire, le traumatisme sévère, la lésion pulmonaire aiguë, le syndrome de détresse respiratoire aiguë, la cholécystite aiguë, les brûlures graves, la pneumonie, les interventions chirurgicales extensives, l'ischémie intestinale, la maladie hépatique aiguë grave, l'encéphalopathie hépatique aiguë grave ou l'insuffisance rénale aiguë. |
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Bibliography: | Application Number: CA20142934567 |