MODIFIED SERPINS FOR THE TREATMENT OF BLEEDING DISORDERS

This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro...

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Main Authors BAGLIN, TREVOR, POLDERDIJK, STEPHANIE, HUNTINGTON, JAMES ANDREW
Format Patent
LanguageEnglish
French
Published 18.06.2015
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Abstract This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.
AbstractList This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.
Author BAGLIN, TREVOR
POLDERDIJK, STEPHANIE
HUNTINGTON, JAMES ANDREW
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DocumentTitleAlternate SERPINES MODIFIEES POUR LE TRAITEMENT DE TROUBLES DE SAIGNEMENT
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Snippet This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to...
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SubjectTerms CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Title MODIFIED SERPINS FOR THE TREATMENT OF BLEEDING DISORDERS
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