MODIFIED SERPINS FOR THE TREATMENT OF BLEEDING DISORDERS

This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro...

Full description

Saved in:
Bibliographic Details
Main Authors BAGLIN, TREVOR, POLDERDIJK, STEPHANIE, HUNTINGTON, JAMES ANDREW
Format Patent
LanguageEnglish
French
Published 18.06.2015
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online AccessGet full text

Cover

More Information
Summary:This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding.
Bibliography:Application Number: CA20142933508