[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

• Main Authors: MATHISON, CASEY JACOB NELSON, LIANG, FANG, NAGLE, ADVAIT SURESH, SUPEK, FRANTISEK, BIGGART, AGNES, YEH, VINCE, MOLTENI, VALENTINA
• Format: Patent
• Language: English; French
• Published: 09.11.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease. La présente invention concerne des composés de formule (A), ou un sel, un tautomère ou un stéréoisomère pharmaceutiquement acceptable de ceux-ci, les variables étant telles que définies dans la description. La présente invention concerne en outre des compositions pharmaceutiques comprenant de tels composés et des procédés d'utilisation de ces composés pour traiter, prévenir, inhiber, améliorer ou éradiquer la pathologie et/ou la symptomatologie d'une maladie provoquée par un parasite, comme la leishmaniose, la trypanosomiase humaine africaine et la maladie de Chagas.