TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

• Main Authors: LOWE, MARTIN ALEXANDER, JACKSON, VICTORIA ELIZABETH, PORTER, JOHN ROBERT, KROEPLIEN, BORIS
• Format: Patent
• Language: English; French
• Published: 18.01.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

81796130 ABSTRACT Compounds of formula (IIA) or N-oxides thereof, or pharmaceutically acceptable salts or solvates thereof, or co-crystals thereof: ,3 IC-N/\-N 1 Q-Z R11/\/---N \ E 16 R15 (IIA) being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. Date Recue/Date Received 2021-05-03 La présente invention concerne une série de dérivés de 4,5,6,7-tétrahydro-1H-imidazo[4,5-c]pyridine substitués, puissant modulateurs de l'activité du TNF-a humain, qui sont donc utiles dans le traitement et/ou la prévention de diverses maladies humaines, notamment les troubles auto-immuns et inflammatoires, les troubles neurologiques et neurodégénératifs, les troubles nociceptifs et de la douleur, les troubles cardiovasculaires, les troubles métaboliques, les troubles oculaires et les troubles oncologiques.