BROMODOMAIN INHIBITORS

The present invention relates to substituted heterocyclic derivative compounds of Formula (l): Formula (l), compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of p...

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Main Authors KALDOR, STEPHEN W, VEAL, JAMES MARVIN, STAFFORD, JEFFREY ALAN, BOLOOR, AMOGH, BETANCORT, JUAN MANUEL, BENNETT, MICHAEL JOHN
Format Patent
LanguageEnglish
French
Published 26.04.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to substituted heterocyclic derivative compounds of Formula (l): Formula (l), compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease. La présente invention concerne des composés dérivés hétérocycliques substitués, des compositions comprenant lesdits composés, et l'utilisation desdits composés et compositions pour la régulation épigénétique par inhibition de la reconnaissance médiée par bromodomaine de régions acétyl-lysine de protéines, telles que des histones. Ces compositions et méthodes sont utilisées dans le traitement du cancer et de maladie néoplasique.
Bibliography:Application Number: CA20142927567