NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. Cette...

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Main Authors KAUFFMAN, GREGORY WAYNE, VERHOEST, PATRICK ROBERT, PETTERSSON, MARTIN YOUNGJIN, TRAN, TUAN PHONG, JOHNSON, DOUGLAS SCOTT, STIFF, CORY MICHAEL, AM ENDE, CHRISTOPHER WILLIAM, SUBRAMANYAM, CHAKRAPANI, PATEL, NANDINI CHATURBHAI, GREEN, MICHAEL ERIC, O'DONNELL, CHRISTOPHER JOHN, STEPAN, ANTONIA FRIEDERIKE
Format Patent
LanguageEnglish
French
Published 06.03.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. Cette invention concerne des composés présentant la structure de la formule I; (I) telle que définie dans la description, et des sels pharmaceutiquement acceptables desdits composés. L'invention concerne également des compositions pharmaceutiques, des procédés de traitement, des procédés de synthèse et des produits intermédiaires correspondants.
Bibliography:Application Number: CA20142925743