IMIDAZOPYRIDAZINES USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY

• Main Authors: MARTEL, JULIEN, FARMER, LUC J, FOURNIER, PIERRE-ANDRE, STURINO, CLAUDIO, LESSARD, STEPHANIE, SZYCHOWSKI, JANEK, ST-ONGE, MIGUEL, YANNOPOULOS, CONSTANTIN, BUBENIK, MONICA, VALLEE, FREDERIC, RAMTOHUL, YEEMAN, LACOSTE, JEAN-ERIC, LIU, BINGCAN, SAYEGH, CAMIL ELIE
• Format: Patent
• Language: English; French
• Published: 02.04.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of GPCRs in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such GPCRs; and the comparative evaluation of new inhibitors of the PAR-2 signaling pathway. The compounds of this invention have formula I: wherein the variables are as defined herein.