ENGINEERED POLYPEPTIDE CONJUGATES

The present invention provides engineered polypeptide conjugates (e.g., antibody-drug- conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods...

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Bibliographic Details
Main Authors STROP, PAVEL, FARIAS, SANTIAGO ESTEBAN, GALINDO CASAS, MERITXELL
Format Patent
LanguageEnglish
French
Published 11.09.2018
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The present invention provides engineered polypeptide conjugates (e.g., antibody-drug- conjugates) comprising specific acyl donor glutamine-containing tags and amine donor agents. The invention also provides methods of making such engineered polypeptide conjugates using transglutaminase and methods of using thereof. La présente invention concerne des conjugués de polypeptides modifiés (par exemples, des conjugués anticorps-médicament-anticorps) comprenant des étiquettes contenant de la glutamine donneuse d'acyle spécifiques et des agents donneurs d'amine. L'invention concerne également des procédés de fabrication de ces conjugués de ces polypeptides modifiés au moyen d'une transglutaminase et des procédés pour les utiliser.
Bibliography:Application Number: CA20142919583