DOSAGE REGIMEN FOR MADCAM ANTAGONISTS

• Main Authors: PRADHAN, VIVEKANANDA, CLARE, ROBERT A, TILLEY, MERA KRISHNAN, PAGE, KAREN MICHELLE, ZHANG, WEIDONG, CATALDI, FABIO, VON SCHACK, DAVID J, BANERJEE, ANINDITA, COMER, GAIL M, HASSAN-ZAHRAEE, MINA, VINCENT, MICHAEL STEVEN, AHMAD, ALAA
• Format: Patent
• Language: English; French
• Published: 09.07.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention provides a method for the treatment of a patient comprising administering to the patient an initial dose of between about 1 mg and about 150 mg of a MAdCAM antagonist antibody. Biomarkers for assessing a patient's response to anti-MAdCAM treatment are also provided. La présente invention concerne une méthode pour le traitement dun patient comprenant ladministration au patient dune dose initiale comprise entre environ 1 mg et environ 150 mg dun anticorps antagoniste de MAdCAM. Linvention concerne également des biomarqueurs pour évaluer la réponse dun patient au traitement anti-MAdCAM.