METHOD FOR PRODUCING RENAL PROGENITOR CELLS AND DRUG COMPRISING THE SAME

• Main Authors: OSAFUNE, KENJI, YAMAGISHI, YUKIKO, TOYOHARA, TAKAFUMI
• Format: Patent
• Language: English; French
• Published: 27.04.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention provides: a method for producing renal precursor cells from intermediate mesoderm cells, the method including a step for cultivating intermediate mesoderm cells in a culture medium that contains a TGFß signal stimulant and a BMP inhibitor; renal precursor cells produced with the method; a drug composition that contains the cells; and a therapeutic agent for renal disease that contains the cells. La présente invention concerne un procédé de production de cellules précurseurs rénales à partir de cellules du mésoderme intermédiaire, ledit procédé comprenant une étape de culture de cellules du mésoderme intermédiaire dans un milieu de culture contenant un stimulant du signal des TGFß et un inhibiteur des BMP ; des cellules précurseurs rénales produites par ledit procédé ; une composition de médicament contenant lesdites cellules ; et un agent thérapeutique utilisable en vue du traitement d'une affection rénale et contenant lesdites cellules.