METHODS AND COMPOSITIONS FOR REDUCING IMMUNOSUPRESSION BY TUMOR CELLS

The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof. La présente invention concerne, en partie, des procéd...

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Main Authors ZHOU, PENGHUI, DRANOFF, GLENN, SHAFFER, DONALD, HACOHEN, NIR, CANTOR, HARVEY I, ALVAREZ ARIAS, DIANA, WUCHERPFENNIG, KAI W
Format Patent
LanguageEnglish
French
Published 28.01.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof. La présente invention concerne, en partie, des procédés permettant de découvrir des cibles d'immunothérapie in vivo, des compositions thérapeutiques (par exemple, ARNsh, cellules capables de produit immunitaire exprimant des ARNsh et/ou récepteurs d'antigènes chimériques (RAC)), et des procédés pour les utiliser.
Bibliography:Application Number: CA20142912389