HEPCIDIN ANALOGUES AND USES THEROF

• Main Authors: FREDERICK, BRIAN T, FOG, JACOB ULRIK, VINK, SIMONE, SHELTON, ANNE PERNILLE TOFTENG, SMYTHE, MARK LESLIE, BOURNE, GREGORY THOMAS, MADALA, PRAVEEN
• Format: Patent
• Language: English; French
• Published: 06.07.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein. La présente invention concerne, entre autres, certains analogues peptidiques d'hepcidine, comprenant des peptides et des dimères de ceux-ci, et l'utilisation des peptides et dimères peptidiques dans le traitement et/ou la prévention d'une variété de maladies, d'états ou de troubles, comprenant le traitement et/ou la prévention de maladies de surcharge en fer, qui comprennent l'hémochromatose héréditaire et les anémies à charge en fer, et d'autres états et troubles décrits ici.