COMPOUNDS FOR STABILIZING RYANODINE RECEPTORS FROM ABERRANT LEVELS OF CALCIUM RELEASE

Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington&#...

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Bibliographic Details
Main Authors DAHL, RUSSELL, STUTZMANN, GRACE E, KAIHO, CHRISTOPHER H
Format Patent
LanguageEnglish
French
Published 24.07.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders. L'invention concerne des procédés et des compositions comprenant des composés aptes à normaliser une dyshoméostase du calcium neuronale. L'invention concerne également des procédés comprenant ces composés pour traiter des troubles neuronaux ou neurologiques, comprenant la maladie d'Alzheimer, la maladie de Parkinson, la maladie de Huntington, une démence fronto-temporale, la maladie de Pick, une encéphalopathie traumatique chronique, une lésion cérébrale traumatique, un accident vasculaire cérébral, une ataxie cérébelleuse, une sclérose en plaques, le syndrome de Down et des troubles CNS liés au vieillissement.
Bibliography:Application Number: CA20142906168