PHENYL SULFONAMIDE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF ARTHRITIS

• Main Authors: PAYETTE, JOSHUA, YOON, HONGCHUL, SCHULTZ, PETER G, YANG, BAIYUAN, CHATTERJEE, ARNAB K, ZHU, SHOUTIAN
• Format: Patent
• Language: English; French
• Published: 23.08.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Described herein are compounds and compositions for the amelioration of arthritis or joint injuries by inducing mesenchymal stem cells into chondrocytes. Described herein is a compound of Formula IIc, or a pharmaceutically acceptable salt, solvate, polymorph, N-oxide, or stereoisomer thereof, for use in ameliorating arthritis or joint injury in a mammal: (see formula IIc) Des composés et des compositions sont décrits pour l'amélioration de la condition d'arthrite ou des blessures articulaires par l'induction des cellules souches mésenchymateuses en chondrocytes. Un composé de formule IIc est décrit ou un sel acceptable sur le plan pharmaceutique, un solvaté, un polymorphe, un N-oxyde ou un stéréo-isomère connexe à utiliser pour l'amélioration de la condition d'arthrite ou des blessures articulaires chez les mammifères : (Formule IIc)