IMMUNOGENIC FUSION POLYPEPTIDES

• Main Authors: JANSEN, KATHRIN UTE, MORAN, JUSTIN KEITH, RUPPEN, MARK EDWARD, DILTS, DEBORAH ANN, VIDUNAS, EUGENE JOSEPH, ANDERSON, ANNALIESA SYBIL
• Format: Patent
• Language: English; French
• Published: 09.04.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

In one aspect, the invention relates to an isolated polypeptide including the amino acid sequence of a carrier polypeptide and the amino acid sequence of an ORF2086 polypeptide. In another aspect, the invention relates to an immunogenic conjugate including ORF2086 polypeptide and a carrier polypeptide. The invention further includes immunogenic compositions and methods for inducing an immune response against Neisseria meningitidis in a mammal. Dans un aspect, l'invention concerne un polypeptide isolé comprenant la séquence d'acides aminés d'un polypeptide support et la séquence d'acides aminés d'un polypeptide ORF2086. Dans un autre aspect, l'invention concerne un conjugué immunogène comprenant un polypeptide ORF2086 et un polypeptide support. L'invention concerne en outre des compositions immunogènes et des procédés d'induction d'une réponse immunitaire contre Neisseria meningitidis chez un mammifère.