N-ACYL-N'-(PYRIDIN-2-YL) UREAS AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES

Described are compounds of Formula I, which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-IR), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c- FMS,...

Full description

Saved in:
Bibliographic Details
Main Authors PATT, WILLIAM C, FLYNN, DANIEL L, YATES, KAREN M, KAUFMAN, MICHAEL D, SAMARAKOON, THIWANKA, VOGETI, LAKSHMINARAYANA, CALDWELL, TIMOTHY MALCOLM
Format Patent
LanguageEnglish
French
Published 21.09.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:Described are compounds of Formula I, which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-IR), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c- FMS, c-KIT, or PDGFR kinases. L'invention concerne des composés de formule I, qui trouvent une utilité dans le traitement de cancers, de maladies auto-immunes et de troubles osseux métaboliques par l'inhibition des c-FMS (CSF-IR), c-KIT et/ou PDGFR kinases. Ces composés trouvent aussi une utilité dans le traitement d'autres maladies mammaliennes médiées par les c-FMS, c-KIT ou PDGFR kinases.
Bibliography:Application Number: CA20142903288