INHIBITORS OF THE KYNURENINE PATHWAY

• Main Authors: BANERJEE, MONALI, RAINA, SUSHIL, MIDDYA, SANDIP, SHRIVASTAVA, RITESH, SMITH, ROGER A, KAPOOR, KAMAL KISHORE, SURYA, ARJUN, VENKATESAN, ARANAPAKAM, YADAV, DHARMENDRA B, YADAV, VEEJENDRA K, THOMPSON, SCOTT K
• Format: Patent
• Language: English; French
• Published: 10.01.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) (see formula I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase. La présente invention concerne de nouveaux inhibiteurs de l'indoleamine 2,3-dioxygénase-1 et/ou de l'indoleamine 2,3-dioxygénase-2 et/ou du tryptophane 2,3-dioxygénase, des métabolites de ceux-ci, et des sels ou des promédicaments pharmaceutiquement acceptables de ces derniers. L'invention concerne également des méthodes de préparation de ces composés. Une quantité thérapeutiquement efficace d'un ou de plusieurs des composés de formule (I) est utile dans le traitement de maladies résultant d'un dérèglement de la voie de la kynurénine. Les composés de formule (I) agissent en inhibant l'activité enzymatique ou l'expression de l'indoleamine 2,3-dioxygénase-1 et/ou de l'indoleamine 2,3-dioxygénase-2 et/ou du tryptophane 2,3-dioxygénase.