QUINOLINE AND QUINAZOLINE COMPOUNDS AND USES THEREOF FOR TREATING AND/OR PREVENTING DISEASES

• Main Authors: NOWAK, PAWEL WOJCIECH, KIM, JINSOO, ONG, WINSTON ZAPANTA, ASKEW, BEN C
• Format: Patent
• Language: English; French
• Published: 10.08.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Described herein are compounds of Formula (1)-(111), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (1)-(111) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating and/or preventing diseases, including proliferative diseases and diseases associated with angiogenesis or aberrant signaling of growth factors, such as cancer, macular degeneration, and diabetic retinopathy, are also provided. La présente invention concerne des composés de formules (I) à (III), leurs sels pharmaceutiquement acceptables, et des compositions pharmaceutiques associées. L'invention concerne également des particules (par exemple des nanoparticules) comprenant des composés de formules (I) à (III), et des compositions pharmaceutiques associées capables de pénétrer à travers le mucus. L'invention concerne également des méthodes d'utilisation des composés ou des compositions pharmaceutiques associées pour traiter et/ou prévenir des maladies.