TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, an...

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Bibliographic Details
Main Authors YOUNG, SCOTT, MANDELL, KENNETH J, KINNEY, WILLIAM A, BRADY, TODD
Format Patent
LanguageEnglish
French
Published 13.06.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
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Summary:The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE. La présente invention concerne le traitement, la prévention et/ou la réduction d'un risque de maladie, trouble ou état pathologique dont la pathogenèse est liée à la toxicité d'un aldéhyde, notamment des troubles oculaires, des troubles cutanés, des états associés aux effets nuisibles d'agents vésicants, et des maladies auto-immunes, inflammatoires, neurologiques et cardiovasculaires, et ce par l'utilisation d'une amine primaire pour piéger des aldéhydes toxiques, tels que MDA et HNE.
Bibliography:Application Number: CA20142898631