AZOLE BENZENE DERIVATIVE HAVING XANTHINE OXIDASE INHIBITORY ACTIVITY

The present invention provides: a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which has an excellent inhibitory activity on xanthine oxidase and is useful as a therapeutic agent or a prophylactic agent for diseases associated with xanthine oxidase, such as gout...

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Bibliographic Details
Main Authors KANAZAWA, CHIKASHI, SHIRAKURA, TAKASHI, KAWANA, ASAHI, TAKAHASHI, YOSHIMASA
Format Patent
LanguageEnglish
French
Published 16.02.2021
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides: a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which has an excellent inhibitory activity on xanthine oxidase and is useful as a therapeutic agent or a prophylactic agent for diseases associated with xanthine oxidase, such as gout, hyperuricemia, tumor lysis syndrome, urinary tract stone, hypertension, dyslipidemia, diabetes, cardiovascular diseases including arteriosclerosis and heart failure, renal diseases including diabetic nephropathy, respiratory diseases including chronic obstructive pulmonary disease, inflammatory bowel disease or autoimmune diseases; and a medicine or a pharmaceutical composition comprising the compound or the salt as an active ingredient. L'invention concerne un composé de formule (I) ou son sel pharmaceutiquement acceptable, qui présente une excellente activité inhibitrice sur la xanthine oxydase et est utilisé comme agent thérapeutique ou agent prophylactique pour les maladies associées à la xanthine oxydase, par exemple la goutte, l'hyperuricémie, le syndrome de lyse tumorale, la lithiase urinaire, l'hypertension, la dyslipidémie, le diabète, les maladies cardiovasculaires dont l'artériosclérose et l'insuffisance cardiaque, les maladies rénales dont la néphropathie diabétique, les maladies respiratoires dont la bronchopneumopathie chronique obstructive, les maladies inflammatoires chroniques de l'intestin ou les maladies auto-immunes. L'invention concerne également un médicament ou une composition pharmaceutique comprenant le composé ou le sel pour principe actif.
Bibliography:Application Number: CA20142897928