ANTIGENS BASED ON NEISSERIA SPECIES ORF 2086 PROTEIN AND COMPOSITIONS COMPRISING SUCH ANTIGENS

• Main Authors: BERNFIELD, LIESEL A, FARLEY, JOHN, METCALF, BENJAMIN J, FLETCHER, LEAH D, ZAGURSKY, ROBERT J, ZLOTNICK, GARY W
• Format: Patent
• Language: English; French
• Published: 01.05.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to Neisseria ORF 2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as immunogenic compositions comprising the same. La présente invention porte sur des protéines ORF 2086 de lespèce Neisseria, des protéines immunogènes à réaction croisée qui peuvent être isolées des souches de Neisseria ou préparées par recombinaison, y compris de leurs parties immunogènes, leurs équivalents biologiques, des anticorps qui se lient de manière immunospécifique aux précédentes et aux séquences dacide nucléique codant chacune des précédentes, ainsi que lutilisation de celles-ci dans les compositions immunogènes qui en renferment.