NOVEL BENZAZEPINE DERIVATIVE AND MEDICAL USE THEREOF

• Main Authors: OHSAWA, YASUSHI, ASANO, YUKIYASU, GOTOH, IZUMI, KASUGAI, NOBUYOSHI, SAKAI, KEITA, IZUCHI, TORU, KITAMOTO, KATSUNORI, YAMADA, YURIE, KURUMAZUKA, DAISUKE, NAGANO, HIROKI, FUJIEDA, HIROKI, KATAOKA, HIROYO, MIYAZAWA, TOSHIYUKI, TAKEUCHI, MITSUAKI, TAKAHASHI, NAOKI, KUNO, YUKA, OKABE, MORIO, HARADA, SATOKO
• Format: Patent
• Language: English; French
• Published: 03.07.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The objective of the present invention is to provide a compound which has V2 receptor agonistic activity. A pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (In general formula (I), R1 represents a group represented by formula (2) or the like; R2 represents a hydrogen atom or a lower alkyl group; R3 represents a lower alkyl group which may be substituted by 1-3 fluorine atoms, or a halogen atom; R4 represents a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group or the like (provided that these heterocyclic groups have at least one nitrogen atom and may be substituted by a lower alkyl group); and R5 represents a lower alkyl group, a halogen atom or the like.) (In formula (2), A represents a lower alkylene group which may be substituted by a lower alkyl group, or the like; R6 represents a hydrogen atom or the like; and R7 represents a hydroxyl group, an aromatic heterocyclic group which may be substituted by a lower alkyl group, a carbamoyl group or the like.)