N-PROP-2-YNYL CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS

• Main Authors: HEIKKINEN, TERHI, PRUSIS, PETERIS, HOLM, PATRIK, SALO, HARRI, ROSLUND, MATTIAS, ARVELA, RIINA
• Format: Patent
• Language: English; French
• Published: 10.11.2020
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Compounds of formula I, (see formula I) wherein A, B, X, Y, Z, and R1-R6, are as defined in the claims. Pharmaceutical compositions comprising such compounds and use in the treatment of diseases linked to the activation of the TRPA 1 (Transient Receptor Potential subfamily A, member 1) receptors. Ce...