N-PROP-2-YNYL CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRPA1 ANTAGONISTS

Compounds of formula I, (see formula I) wherein A, B, X, Y, Z, and R1-R6, are as defined in the claims. Pharmaceutical compositions comprising such compounds and use in the treatment of diseases linked to the activation of the TRPA 1 (Transient Receptor Potential subfamily A, member 1) receptors. Ce...

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Main Authors HEIKKINEN, TERHI, PRUSIS, PETERIS, HOLM, PATRIK, SALO, HARRI, ROSLUND, MATTIAS, ARVELA, RIINA
Format Patent
LanguageEnglish
French
Published 10.11.2020
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Compounds of formula I, (see formula I) wherein A, B, X, Y, Z, and R1-R6, are as defined in the claims. Pharmaceutical compositions comprising such compounds and use in the treatment of diseases linked to the activation of the TRPA 1 (Transient Receptor Potential subfamily A, member 1) receptors. Cette invention concerne des composés de formule I - A, B, X, Z et R1-R6 dans la formule étant tels que définis dans les revendications, qui manifestent une activité TRPA 1 et sont par conséquent utiles à titre de modulateurs de TRPA1.
Bibliography:Application Number: CA20132884922