NOVEL DRUG-PROTEIN CONJUGATES

Specific conjugates containing auristatins and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates. Also described are specific conjugates of drugs and a binding protein o...

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Bibliographic Details
Main Authors GODWIN, ANTONY, BADESCU, GEORGE, FRIGERIO, MARK, BURT, JOHN
Format Patent
LanguageEnglish
French
Published 01.05.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Specific conjugates containing auristatins and a binding protein or peptide, and processes for making them, are described. The conjugates use specific linker technology which gives advantages over known antibody-drug conjugates. Also described are specific conjugates of drugs and a binding protein or peptide in which more than one copy of the drug is present. Conjugués spécifiques contenant des auristatines et une protéine ou un peptide de liaison, et procédés de préparation correspondants. Ces conjugués utilisent une technologie de liaison spécifique qui procure des avantages par rapport à des conjugués anticorps-médicament connus. La présente invention concerne également des conjugués spécifiques de médicaments et d'une protéine ou d'un peptide de liaison, dans lesquels plus d'une copie du médicament est présente.
Bibliography:Application Number: CA20132884299