CHEMICAL COMPOSITIONS AND METHODS FOR ENHANCING TRANSDERMAL DELIVERY OF THERAPEUTIC AGENTS

• Main Authors: KYDONIEUS, AGIS, VALIA, KIRTI H
• Format: Patent
• Language: English; French
• Published: 15.12.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present application discloses chemical compositions and methods for enhancing the transdermal permeation of therapeutic agents through skin. The chemical compositions and methods of the invention can include combinations of a first fatty acid having about 14 or more carbon atoms and a second fatty acid having about 10 or less carbon atoms. These compositions are useful for the delivery of therapeutic agents, in particular hard to deliver drugs such as those that have fused rings, including ondansetron, and large drugs such as peptides. The compositions of the invention can be formulated as transdermal gels, lotions, creams, transdermal patches, sprays or mists. La présente invention concerne des compositions chimiques et des procédés qui permettent d'améliorer la pénétration transdermique d'agents thérapeutiques à travers la peau. Les compositions chimiques et les procédés de l'invention peuvent comprendre des combinaisons d'un premier acide gras ayant environ au moins 14 atomes de carbone et un second acide gras ayant au plus environ 10 atomes de carbone. Ces compositions sont utiles pour l'administration d'agents thérapeutiques, en particulier des médicaments difficiles à administrer tels que ceux qui ont des cycles fusionnés, comprenant l'ondansétron, et de grands médicaments tels que des peptides. Les compositions de l'invention peuvent être formulées en tant que gels, lotions, crèmes, timbres, brouillards ou brumisations transdermiques.