HETEROCYCLYL PYRIMIDINE ANALOGUES AS TYK2 INHIBITORS

• Main Authors: MOREL, ADELINE, MAJOR, JEREMY, JONES, ALISON, HARRISON, RICHARD JOHN, SUNOSE, MIHIRO, RAMSDEN, NIGEL, ADREGO, RITA, CONVERY, LAURA, LYNCH, ROSEMARY
• Format: Patent
• Language: English; French
• Published: 28.11.2013
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds of formula (I), wherein R, R1, X1 to X5 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds as well as their use as medicaments. La présente invention concerne des composés de formule (I), dans laquelle R, R1, X1 à X5 présentent la signification telle que citée dans la description et les revendications. Lesdits composés sont utiles comme inhibiteurs de TYK2 destinés au traitement ou à la prophylaxie de troubles immunologiques, inflammatoires, auto-immuns, allergiques et de maladies médiées de manière immunologique. L'invention concerne également des compositions pharmaceutiques comprenant lesdits composés ainsi que leur utilisation comme médicaments.