HERPESVIRUS COMPOSITIONS AND RELATED METHODS

The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at ieast two or more pharmaceutically acceptable exctpients, at ieast one of which is...

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Bibliographic Details
Main Authors MUNDLE, SOPHIA, LI, QINGLIAN, RAHMAN, NAUSHEEN, HAMBERGER, JOHN, DELAGRAVE, SIMON, ANDERSON, STEPHEN
Format Patent
LanguageEnglish
French
Published 20.04.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at ieast two or more pharmaceutically acceptable exctpients, at ieast one of which is histidsne and at least one of which is a sugar or sugar alcohol. The composstions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization. La présente invention concerne des compositions liquides et séchées comprenant un virus herpétique vivant, atténué ou génétiquement modifié, et des procédés de préparation de telles compositions. Selon un aspect, la composition comprend au moins deux excipients pharmaceutiquement acceptables, dont au moins l'un est de l'histidine et dont au moins l'un est un sucre ou un alcool de sucre. La composition retient un titre infectieux suffisamment élevé suivant les étapes de stockage ou de fabrication à grande échelle, telles que la lyophilisation.
Bibliography:Application Number: CA20132873775