PROCESS FOR EX-VIVO EXPANSION OF HEMATOPOIETIC STEM CELLS IN A BIOREACTOR

The present invention refers to a process of ex vivo expansion of stem cells, in a bioreactor, in particular hematopoietic stem/progenitor cells co-cultured with mesenchymal stem cells immobilized on microcarriers, for transplantation. The process comprises the steps of: a) forming a suspension of m...

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Main Authors ANDRADE, PEDRO MIGUEL ZACARIAS, SANTOS, FRANCISCO FERREIRA DOS, ALMEIDA-PORADA, MARIA DA GRACA NORTADAS DUARTE DE, SILVA, CLAUDIA ALEXANDRA MARTINS LOBATO DA, CABRAL, JOAQUIM MANUEL SAMPAIO
Format Patent
LanguageEnglish
French
Published 26.09.2013
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present invention refers to a process of ex vivo expansion of stem cells, in a bioreactor, in particular hematopoietic stem/progenitor cells co-cultured with mesenchymal stem cells immobilized on microcarriers, for transplantation. The process comprises the steps of: a) forming a suspension of mesenchymal stem cells immobilized on microcarriers, b) inoculating in a bioreactor containing an expansion medium, hematopoietic cells co-cultured with mesenchymal stem cells immobilized on microcarriers c) expansion of hematopoietic cells. The process of the invention is capable of being implemented in a Kit.
Bibliography:Application Number: CA20132868167