ANTIFUNGAL AGENTS AND USES THEREOF

The invention features echinocandin class compounds that can be useful for the treatment of fungal infections. The echinocandin class compounds have been modified such that they can exhibit (i) activity against one or more fungal species or genera; (ii) increased aqueous solubility and/or amphiphili...

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Main Authors RADHAKRISHNAN, BALASINGHAM, JAMES, KENNETH DUKE, LAUDEMAN, CHRISTOPHER PATRICK, MALKAR, NAVDEEP BALKRISHNA
Format Patent
LanguageEnglish
French
Published 08.10.2019
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
CHEMISTRY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TRAPPING
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Summary:The invention features echinocandin class compounds that can be useful for the treatment of fungal infections. The echinocandin class compounds have been modified such that they can exhibit (i) activity against one or more fungal species or genera; (ii) increased aqueous solubility and/or amphiphilicity; (iii) have an increased therapeutic index; (iv) suitability for topical administration; (v) suitability for intravenous administration; (vi) have an increased volume of distribution; and/or (vii) have an increased elimination half-life. La présente invention concerne des composés de la classe des échinocandines. Les composés peuvent être utiles pour le traitement des infections fongiques.
Bibliography:Application Number: CA20122865791