CRYSTALLINE FORM OF A SUCCINATE SALT

This invention relates to a new crystalline form of the succinate salt of the epithelial sodium channel (ENaC) blocker 3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8- triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester, pharmaceut...

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Bibliographic Details
Main Authors TUFILLI, NICOLA, HOWSHAM, CATHERINE, LINDENBERG, CHRISTIAN, PERLBERG, ANETT
Format Patent
LanguageEnglish
French
Published 02.06.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to a new crystalline form of the succinate salt of the epithelial sodium channel (ENaC) blocker 3-(3-{2-[(E)-3,5-Diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8- triaza-spiro[4.5]decane-8-carbonyl}-benzenesulfonylamino)-propionic acid dipropylcarbamoylmethyl ester, pharmaceutical compositions comprising said crystalline form, uses of said crystalline form and pharmaceutical compositions, and methods for preparing said crystalline form. La présente invention concerne une nouvelle forme cristalline du sel de succinate du bloqueur du canal sodique épithélial (ENaC), ester dipropylcarbamoylméthylique de l'acide 3-(3-{2-[(E)-3,5-diamino-6-chloro-pyrazine-2-carbonylimino]-1,3,8-triaza-spiro[4.5]décane-8-carbonyle}-benzènesulfonylamino)-propionique, des compositions pharmaceutiques comprenant ladite forme cristalline, des utilisations de ladite forme cristalline et des compositions pharmaceutiques, ainsi que des procédés de préparation de ladite forme cristalline.
Bibliography:Application Number: CA20132865536