4,4-DISUBSTITUTED-1,4-DIHYDROPYRIMIDINES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1-R5, B and Z have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containi...

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Main Authors RABOISSON, PIERRE JEAN-MARIE BERNARD, VANDYCK, KOEN, HACHE, GEERWIN YVONNE PAUL, ROMBOUTS, GEERT, VERSCHUEREN, WIM GASTON
Format Patent
LanguageEnglish
French
Published 31.03.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1-R5, B and Z have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy. L'invention concerne des inhibiteurs de la réplication du VHB de formule (I), y compris les formes isomères stéréochimiques et les sels, hydrates et solvates associés, R1 à R5, B et Z ayant la signification telle que définie dans le présent document. La présente invention concerne également des procédés de préparation desdits composés, des compositions pharmaceutiques les contenant et leur utilisation, seuls ou en combinaison avec d'autres inhibiteurs du VHB, pour le traitement du VHB.
Bibliography:Application Number: CA20132858647