CHOLINE SALT OF AN ANTI - INFLAMMATORY SUBSTITUTED CYCLOBUTENEDIONE COMPOUND

In one aspect the invention provides a solid pharmaceutical composition comprising a) choline salt of 6-chloro-3-[2-(1-ethyl-propylamino)-3,4-dioxo-cyclobut-1-enylamino]-2-hydroxy-N-methoxy-N-methyl-benzenesulfonamide; b) an alkalizing agent; c) a precipitation inhibiting agent; and d) an additional...

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Bibliographic Details
Main Authors AMBARKHANE, AMEET VIJAY, TIMPE, CARSTEN, BAETTIG, URS, MAULER, ARNAUD
Format Patent
LanguageEnglish
French
Published 22.10.2019
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:In one aspect the invention provides a solid pharmaceutical composition comprising a) choline salt of 6-chloro-3-[2-(1-ethyl-propylamino)-3,4-dioxo-cyclobut-1-enylamino]-2-hydroxy-N-methoxy-N-methyl-benzenesulfonamide; b) an alkalizing agent; c) a precipitation inhibiting agent; and d) an additional pharmaceutically acceptable carrier. Compounds of the invention are useful in the treatment of conditions and diseases mediated by CXCR2, and in particular for use in the treatment of inflammatory, obstructive, or allergic conditions and diseases. La présente invention concerne une 6-chloro-3-[2-(1-éthyl-propyl-amino)-3,4-dioxo-cyclobut-1-enyl-amino]-2-hydroxy-N-méthoxy-N-méthyl-benzène-sulfonamide choline. L'invention concerne également des compositions pharmaceutiques et des formes posologiques orales contenant ledit composé. L'invention concerne enfin un procédé permettant d'utiliser de telles compositions et formes posologiques pour traiter des personnes souffrant de maladies et d'états inflammatoires, obstructifs, ou allergiques.
Bibliography:Application Number: CA20122846510