CYCLOSPORIN DERIVATIVES

The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscl...

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Main Authors DINKEL, KLAUS, NUSSBAUMER, PETER, BUKRINSKY, MICHAEL, ERDMANN, FRANK, KUHLING, JAN, MALESEVIC, MIROSLAV, CONSTANT, STEPHANIE, RUHTER, GERD, FISCHER, GUNTER
Format Patent
LanguageEnglish
French
Published 08.09.2020
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect. La présente invention concerne de nouveaux dérivés de cyclosporine non aptes à pénétrer dans les cellules. Les composés selon la présente invention s'utilisent en médecine, et plus particulièrement pour le traitement/le diagnostic de maladies inflammatoires aiguës et chroniques, d'infections virales, du cancer, de maladies musculaires dégénératives, de maladies neurodégénératives et de lésions associées à une altération de l'homéostase du calcium. Par ailleurs, ces nouveaux dérivés de cyclosporine n'ont pas d'effet immunosuppresseur.
Bibliography:Application Number: CA20122845663