PROTEIN CARRIER-LINKED PRODRUGS

The present invention relates to water-soluble protein carrier- linked prodrugs wherein the protein carrier comprises an amino acid sequence consisting of at least 100 amino acid residues forming random coil conformation and comprising alanine, serine and proline residues. It further relates to phar...

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Bibliographic Details
Main Authors HERSEL, ULRICH, VETTER, DIRK
Format Patent
LanguageEnglish
French
Published 25.08.2020
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to water-soluble protein carrier- linked prodrugs wherein the protein carrier comprises an amino acid sequence consisting of at least 100 amino acid residues forming random coil conformation and comprising alanine, serine and proline residues. It further relates to pharmaceutical compositions comprising said water-soluble protein carrier- linked prodrugs, their use as a medicament as well as methods of treatment and administration. La présente invention concerne des promédicaments liés à un excipient protéique hydrosoluble, l'excipient protéique comportant une séquence d'acides aminés d'au moins 100 résidus d'acides aminés formant une conformation en pelote statistique et comportant des résidus d'alanine, de sérine et de proline. L'invention concerne également des compositions pharmaceutiques comportant lesdits promédicaments liés à un excipient protéique hydrosoluble, leur utilisation en tant que médicament ainsi que des méthodes de traitement et d'administration.
Bibliography:Application Number: CA20122843504