DENDRIMERS COMPRISING TERMINAL PHARMACEUTICALLY ACTIVE AGENTS AND TERMINAL PHARMACOKINETIC MODIFYING AGENTS
The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl gr...
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| Main Authors | , , |
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| Format | Patent |
| Language | English French |
| Published |
30.03.2021
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described.
La présente invention concerne une macromolécule comprenant un dendrimère présentant des groupes amino de surface auxquels au moins deux groupes terminaux différents sont fixés incluant un agent pharmaceutiquement actif et un agent modifiant la pharmacocinétique, l'agent pharmaceutiquement actif comprenant un groupe hydroxyle et étant fixé au groupe amino de surface du dendrimère grâce à un coupleur diacide. Des compositions pharmaceutiques comprenant les macromolécules et des procédés de traitement utilisant les macromolécules sont également décrits. |
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| AbstractList | The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described.
La présente invention concerne une macromolécule comprenant un dendrimère présentant des groupes amino de surface auxquels au moins deux groupes terminaux différents sont fixés incluant un agent pharmaceutiquement actif et un agent modifiant la pharmacocinétique, l'agent pharmaceutiquement actif comprenant un groupe hydroxyle et étant fixé au groupe amino de surface du dendrimère grâce à un coupleur diacide. Des compositions pharmaceutiques comprenant les macromolécules et des procédés de traitement utilisant les macromolécules sont également décrits. |
| Author | KARELLAS, PETER KELLY, BRIAN DEVLIN OWEN, DAVID |
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| DocumentTitleAlternate | DENDRIMERES COMPRENANT DES AGENTS PHARMACEUTIQUEMENT ACTIFS DU TERMINAL ET DES AGENTS MODIFIANT LA PHARMACOCINETIQUE DU TERMINAL |
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| Notes | Application Number: CA20122837979 |
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| RelatedCompanies | STARPHARMA PTY LTD |
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| Snippet | The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are... |
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| Title | DENDRIMERS COMPRISING TERMINAL PHARMACEUTICALLY ACTIVE AGENTS AND TERMINAL PHARMACOKINETIC MODIFYING AGENTS |
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