DENDRIMERS COMPRISING TERMINAL PHARMACEUTICALLY ACTIVE AGENTS AND TERMINAL PHARMACOKINETIC MODIFYING AGENTS

The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl gr...

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Bibliographic Details
Main Authors KARELLAS, PETER, KELLY, BRIAN DEVLIN, OWEN, DAVID
Format Patent
LanguageEnglish
French
Published 30.03.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a macromolecule comprising a dendrimer having surface amino groups to which at least two different terminal groups are attached including a pharmaceutically active agent and a pharmacokinetic modifying agent, the pharmaceutically active agent comprising a hydroxyl group and being attached to the surface amino group of the dendrimer through a diacid linker. Pharmaceutical compositions comprising the macromolecules and methods of treatment using the macromolecules are also described. La présente invention concerne une macromolécule comprenant un dendrimère présentant des groupes amino de surface auxquels au moins deux groupes terminaux différents sont fixés incluant un agent pharmaceutiquement actif et un agent modifiant la pharmacocinétique, l'agent pharmaceutiquement actif comprenant un groupe hydroxyle et étant fixé au groupe amino de surface du dendrimère grâce à un coupleur diacide. Des compositions pharmaceutiques comprenant les macromolécules et des procédés de traitement utilisant les macromolécules sont également décrits.
Bibliography:Application Number: CA20122837979