CHIRAL SYNTHESIS OF N-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-6-METHOXYPHENYL}-1-[2,3-DIHYDROXY-PROPYL]CYCLOPROPANESULFONAMIDES
The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate co...
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| Main Authors | , |
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| Format | Patent |
| Language | English French |
| Published |
02.04.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2- fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy- propyl]cyclopropanesulfonamide.
L'invention concerne un nouveau procédé énantiosélectif de préparation d'énantiomères S et R de N-{3,4-difluoro-2-[(2-fluoro-4-iodophényl)amino]-6-5 méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide. L'invention concerne également de nouveaux composés intermédiaires ainsi que leur utilisation dans la préparation des énantiomères S et R de N-{3,4-difluoro-2-[(2- fluoro-4-iodophényl)amino]-6-méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide. |
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| AbstractList | The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2- fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy- propyl]cyclopropanesulfonamide.
L'invention concerne un nouveau procédé énantiosélectif de préparation d'énantiomères S et R de N-{3,4-difluoro-2-[(2-fluoro-4-iodophényl)amino]-6-5 méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide. L'invention concerne également de nouveaux composés intermédiaires ainsi que leur utilisation dans la préparation des énantiomères S et R de N-{3,4-difluoro-2-[(2- fluoro-4-iodophényl)amino]-6-méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide. |
| Author | MAYER, AGATHE CHRISTINE FEY, PETER |
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| Snippet | The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5... |
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| Title | CHIRAL SYNTHESIS OF N-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-6-METHOXYPHENYL}-1-[2,3-DIHYDROXY-PROPYL]CYCLOPROPANESULFONAMIDES |
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