CHIRAL SYNTHESIS OF N-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-6-METHOXYPHENYL}-1-[2,3-DIHYDROXY-PROPYL]CYCLOPROPANESULFONAMIDES

The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate co...

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Bibliographic Details
Main Authors FEY, PETER, MAYER, AGATHE CHRISTINE
Format Patent
LanguageEnglish
French
Published 02.04.2019
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2- fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy- propyl]cyclopropanesulfonamide. L'invention concerne un nouveau procédé énantiosélectif de préparation d'énantiomères S et R de N-{3,4-difluoro-2-[(2-fluoro-4-iodophényl)amino]-6-5 méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide. L'invention concerne également de nouveaux composés intermédiaires ainsi que leur utilisation dans la préparation des énantiomères S et R de N-{3,4-difluoro-2-[(2- fluoro-4-iodophényl)amino]-6-méthoxyphényl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide.
Bibliography:Application Number: CA20122837162