MONENSIN DERIVATIVES FOR THE TREATMENT AND PREVENTION OF PROTOZOAL INFECTIONS

This invention relates to novel polyether ionophores, formulations comprising same, and to methods of making and using these compounds and formulations for the treatment and/or prevention of parasitic infection in animals and humans. These compounds exhibit improved safety profiles and/or efficacies...

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Main Authors LEMAIRE, MARC, ANDRIOLETTI, BRUNO, DELAVEAU, JEAN, PELLET-ROSTAING, STEPHANE, VIALLE, EMILIE
Format Patent
LanguageEnglish
French
Published 12.11.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to novel polyether ionophores, formulations comprising same, and to methods of making and using these compounds and formulations for the treatment and/or prevention of parasitic infection in animals and humans. These compounds exhibit improved safety profiles and/or efficacies as compared to parent compounds. In particular, compounds of formula 3a, 3b, 3c, 4c, 6a, 8b, 12, 19, 26, 27, 31, as defined in the specification, and salts thereof, are provided. Cette invention concerne de nouveaux ionophores polyéthers, des formulations les comportant et des procédés de fabrication et d'utilisation de ces composés et des formulations pour le traitement et/ou la prévention d'infections parasitaires chez des animaux et des êtres humains. Ces composés présentent des profils d'innocuité améliorés et/ou des efficacités améliorées en comparaison avec des composés parents.
Bibliography:Application Number: CA20112818563