4-SUBSTITUTED-3-BENZYLOXY-BICYCLO[3.1.0]HEXANE COMPOUNDS AS MGLUR 2/3 ANTAGONISTS

• Main Authors: TROMICZAK, ERIC GEORGE, CHAPPELL, MARK DONALD, DRESSMAN, BRUCE ANTHONY, ORNSTEIN, PAUL LESLIE, FIVUSH, ADAM MICHAEL, VETMAN, TATIANA NATALI, MITCH, CHARLES HOWARD
• Format: Patent
• Language: English; French
• Published: 29.03.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to an mGlu2/3 receptor antagonist of Formula (I): (see formula I) its uses, including in treatment of depressive disorders and disorders of excessive sleepiness. Methods for preparation of the said receptor antagonist are also described in the present application. L...